Expression of S100A4 protein in hepatocellular carcinoma and its clinical implications / 肿瘤

ABSTRACT

Objective: To explore the expressions of S100A4 protein in hepatocellular carcinoma (HCC), cirrhotic liver, adjacent non-cancerous liver and normal liver tissues and their clinical implications. Methods: Tissue microarray combined with immunohistochemistry (IHC) was used to evaluate the differential expressions of S100A4 protein in HCC-related tissues, and their clinical implications were statistically analyzed. Results: Immunohistochemical staining showed that the positive staining of S100A4 protein was higher in the specimens of primary HCC (70.2%), liver cirrhosis (54.4%), and adjacent non-cancerous liver tissues (41.7%) compared with that in normal liver tissues (0.0%). Biological statistic analysis revealed that S100A4 protein expression influenced the survival time of HCC patients. The patients with weak expression of S100A4 had longer survival time than those with over-expression of S100A4 protein (P = 0.040). Conclusion: The order of the expression levels of S100A4 protein in HCC-related tissues is HCC>adjacent non-cancerous liver > cirrhotic liver > normal liver. In HCC patients without hepatic microvascular invasion, positive expression of S100A4 protein significantly decreases their postoperative survival rate.