The effect of realgar on apoptosis of transplanted ovarian SKOV3 carcinoma cells in nude mice / 肿瘤

ABSTRACT

Objective: To observe the effect of traditional Chinese medicine, realgar, on apoptosis and angiogenesis of ovarian carcinoma cells. Methods: The anti-tumor effects of realgar were observed in nude mice bearing ovarian transplanted carcinoma. Apoptosis and the expression of vascular endothelial growth factor were determined by flow cytometry, fluorescence microscopy, transmission electron microscopy, and immunohistochemical methods. Results: Realgar induced apoptosis and inhibited the growth of ovarian transplanted tumors in nude mice. Realgar also blocked the angiogenesis, inhibited the DNA synthesis, and prolonged the survival time of nude mice. Conclusion: Realgar exerted its anti-tumor effect through multiple pathways such as inducing apoptosis, blocking angiogenesis, inhibiting DNA synthesis and had a wide foreground for application.