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Expressions of heparanase and CD44v6 in osteosarcoma tissues and their correlations / 肿瘤
Tumor ; (12): 817-820, 2007.
Artículo en Chino | WPRIM | ID: wpr-849497
ABSTRACT

Objective:

To study the expression of heparanase and CD44v6 in osteosarcoma and analyze the correlation between them.

Methods:

The expressions of heparanase and CD44v6 in human osteosarcoma were detected by immunohistochemical staining.

Results:

The positive rates of heparanase and CD44v6 protein in osteosarcoma tissues were significantly higher in osteosarcoma tissues than in osteochondroma (79.6% vs 20.0% and 55.1% vs 25.0%, P < O. 05). Expressions of heparanase and CD44v6 had positive correlation (r=0.663, P < 0.001). Both of them were closely associated with clinical stage and metastasis of osteosarcoma.

Conclusion:

Overexpressions of heparanase and CD44v6 in human osteosarcoma may stimulate the adhesion, invasion, and metastasis of osteosarcoma.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Tumor Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Tumor Año: 2007 Tipo del documento: Artículo