Relationship of expressions of hepatocyte growth factor and endothelin converting enzymes with lymphoid metastasis and prognosis in non small cell lung carcinoma / 肿瘤

ABSTRACT

Objective: To investigate the expressions of hepatocyte growth factor (HGF) and endothelin converting enzymes (ECE) in non small cell lung carcinoma (NSCLC) and their association with lymphoid metastasis and prognosis. Methods: Expression of HGF and ECE in 77 cases of patients with NSCLC were detected by immunohistochemical method. The relationship between the expressions of HGF and ECE with tumor size, smoking, histological type, differentiation degree, lymphoid metastasis, and prognosis was analyzed. Results: The positive rates of HGF and ECE expression were 44% and 45%, respectively. The expressions of HGF and ECE were positively associated with lymphoid metastasis (P = 0.003 and 0.001, r = 0. 339 and 0. 467, respectively), and negatively with clinical stage and survival time (P 0. 05). Conclusion: The expressions of HGF and ECE are closely associated with lymphoid metastasis and prognosis in NSCLC. Over-expressions of HGF and ECE imply poor prognosis of NSCLC patients.