Correlation of HPA and CXCR4 expressions with the invasion and metastasis of hepatocellular carcinoma / 肿瘤

ABSTRACT

Objective: To investigate the expressions of heparanase (HPA) and chemokine receptor 4 (CXCR4) in hepatocellular carcinoma (HCC) and their correlations with the invasion and metastasis of HCC. Methods: The expressions of HPA and CXCR4 in HCCs, peri-cancerous tissues, and normal liver tissues were detected by immunohistochemical method. Statistical analysis was used to determine the relationship between their expressions and clinicopathological features. Results: HPA and CXCR4 were over-expressed in HCC tissues compared with that in peri-cancerous tissues and normal liver tissues (P<0.05). The expressions of HPA in HCC correlated with tumor size, intrahepatic or lymphatic metastasis and tumor differentiation (P<0.05); the expression of CXCR4 in HCC correlated with intrahepatic or lymphatic metastasis and tumor thrombosis (P<0.05). There was a positive relationship between HPA and CXCR4 expression (r = 0.313, P=0.027). Conclusion: HPA and CXCR4 play a synergistic role in the initiation, progression, invasion, and metastasis of HCC.