Progress of effects of 14-3-3 protein on gastric cancer and its mechanism / 解放军医学杂志

ABSTRACT

14-3-3 proteins are a highly conserved family of cellular proteins, and widely expressed in all eukaryotes. Because they can bind to a variety of functional signal proteins, so be regarded as "bridge proteins" in protein interaction. Studies have shown that the expression level of 14-3-3 protein family in malignant tumors is closely related to tumor size, depth of invasion and metastasis. Some other studies have shown that 14-3-3 protein plays a pivotal role in cell signal transduction, control of cell cycle process and regulation of apoptosis, and plays an important role in the development of gastric cancer, proliferation, invasion, prognosis and drug resistance, so is expected to become a novel therapeutic target for gastric cancer. The present paper aims to expound the role and relevant mechanisms of 14-3-3 protein in gastric cancer.