Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System
Journal of Neurogastroenterology and Motility
;
: 193-200, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-84979
ABSTRACT
Serum response factor (SRF) is a master transcription factor of the actin cytoskeleton that binds to highly conserved CArG boxes located within the majority of smooth muscle cell (SMC)-restricted promoters/enhancers. Although most studies of SRF focus on skeletal muscle, cardiac muscle, and vascular SMCs, SRF research has recently expanded into the gastrointestinal (GI) system. Genome scale analyses of GI SMC transcriptome and CArG boxes (CArGome) have identified new SRF target genes. In addition to circular and longitudinal smooth muscle layers, SRF is also expressed in GI mucosa and cancers. In the GI tract, SRF is the central regulator of genes involved in apoptosis, dedifferentiation, proliferation, and migration of cells. Since SRF is the cell phenotypic modulator, it may play an essential role in the development of myopathy, hypertrophy, ulcers, gastric and colon cancers within the GI tract. Given the multi-functional role displayed by SRF in the digestive system, SRF has received more attention emerging as a potential therapeutic target. This review summarizes the findings in SRF research pertaining to the GI tract and provides valuable insight into future directions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera Gástrica
/
Factores de Transcripción
/
Citoesqueleto de Actina
/
Genoma
/
Apoptosis
/
Neoplasias del Colon
/
Músculo Esquelético
/
Factor de Respuesta Sérica
/
Células Musculares
/
Miocitos del Músculo Liso
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Journal of Neurogastroenterology and Motility
Año:
2016
Tipo del documento:
Artículo
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