Expression and clinical significance of cellular prion protein in rectal cancer and adenoma / 解放军医学杂志

ABSTRACT

Objective To determine the expressions of cellular prion protein (PrPC) in normal rectal mucosa, rectal adenoma and rectal carcinoma tissues, and to study the relationship of PrPC with development and progression of rectal carcinoma. Methods Immunohistochemical method (SP method) was used to determine the expressions of PrPC in rectal carcinoma (60 samples), rectal adenoma (20 samples) and normal rectal mucosa (20 samples), and the correlations between the expression of PrPC in rectal carcinoma tissue, and clinical pathological parameters including sex, tumor differentiation, clinical stages, lymph node metastasis, etc. were analyzed. Results PrPC was expressed in normal rectal mucosa, rectal adenoma and rectal carcinoma tissues. The positive rate of PrPC expression in rectal carcinoma (65%) was significantly higher than that in rectal adenoma (35%) and normal rectal mucosa (15%) with statistical significance (PC was closely related with tumor differentiation, TNM stage and lymph node metastasis (P0.05). Conclusion PrPC may play an important role in the process of development, progression and metastasis of rectal carcinoma.