Effects of compound amino acids capsule on the immunological function of naval servicemen / 解放军医学杂志

ABSTRACT

Objective To investigate the effects of the compound amino acids capsule on the immunological function of the naval servicemen during military activity. Methods The subjects included 100 officers and soldiers, whose Modified Fatigue Rating Scale (MFIS) scores were >21 points. The participants were randomly divided into two groups, namely, the amino acids capsule group and placebo group (n=50). Under the condition of military operations, either amino acids capsule (8 kinds of essential amino acids and 11 kinds of vitamins were contained) or placebo capsule was given for 14 days continuously. The humoral immune indices, i.e., IgG, IgA, IgM, and complements C3 and C4, were measured with immunoturbidimetry. The percentage of peripheral blood CD subsets was measured using flow cytometry on the first day and 14th day. Results The levels of IgG, IgM, and complement C3 in the capsule group were significantly higher on the 14th day than on the first day (P<0.05), and no significant difference of their levels was observed in the placebo group. The CD3+CD4+ T lymphocytes and CD3- CD19+ B lymphocytes in the capsule group on the 14th day were higher than those on the first day, whereas the CD3-CD56+NK lymphocytes decreased significantly (P<0.05). There was no significant difference in the placebo group. Conclusion Compound amino acids capsule can improve the humoral and cellular immunological function of naval servicemen.