New Synthetic Surfactants for Neonates
Journal of the Korean Society of Neonatology
;
: 184-194, 2012.
Artículo
en Coreano
| WPRIM
| ID: wpr-85057
ABSTRACT
The benefits of exogenous synthetic or animal-derived natural surfactants for treatment of respiratory distress syndrome (RDS) are well established. Although synthetic surfactants have potential safety advantages over animal-derived products, they seem to be clinically inferior to animal-derived natural surfactant, based on the results of numerous comparative trials. In recent years, however, synthetic surfactant has experienced a surge in breakthroughs to the point of rivaling natural surfactant, mainly due to the development of protein-containing synthetic surfactant. This article will review the historical background on the development of artificial pulmonary surfactant, compositional and physicochemical aspects on pulmonary surfactant lipids and proteins, results of comparative trials among natural, protein-free and protein-containing surfactants, and current status of development of protein-containing surfactants for treatment of RDS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tensoactivos
/
Tensión Superficial
/
Surfactantes Pulmonares
/
Recien Nacido Prematuro
/
Proteínas
/
Enfermedad de la Membrana Hialina
Límite:
Humanos
/
Recién Nacido
Idioma:
Coreano
Revista:
Journal of the Korean Society of Neonatology
Año:
2012
Tipo del documento:
Artículo
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