Research progress on chemical constituents and biological activities of Aphanamixis grandifolia / 中草药

ABSTRACT

Aphanamixis grandifolia, a perennial herb of genus Aphanamixis (Meliaceae), has the effect of relaxing sinew and activating collaterals, dredging arthralgia, expelling wind-evil and removing wetness, etc. Previous phytochemical investigations on this plant resulted in the isolation of various terpenoid derivatives, including limonoids, tirucallane-type, dammarane-type, and cycloartane-type triterpenoids, as well as diterpenoids and sesquiterpenoids. Moreover, bioactivities of those compounds were evaluated, which displayed extensive biological properties, such as antibacterial, insecticidal, antineoplastic, anti-inflammatory, antimalarial, and antibacterial activities, etc. In this paper, the systematic classification, chemical constituents, and biological activities of A. grandifolia were summarized. It may provide the reference for the further studies of this plant.