Research progress on “incompatibility” and “compatibility” of Genkwa Flos and Glycyrrhizae Radix et Rhizoma / 中草药

ABSTRACT

“Incompatibility” is the focus of the “Eighteen Incompatible Medicaments” in Chinese materia medica. At present, most experts in traditional Chinese medicine supported that “incompatibility” is relative, that is, the conversion between incompatibility and appropriate compatibility can occur under certain conditions. Genkwa Flos and Glycyrrhizae Radix et Rhizoma are one of the representative of incompatible pairs in “Eighteen Incompatible Medicaments”, which had been well studied. This paper summarized the research progress of the incompatible pairs of Genkwa Flos and Glycyrrhizae Radix et Rhizoma from seven aspects of material basis, pharmacological toxicology, drug metabolism and metabolomics, incompatibility mechanism, gut microbiota, clinical application and compatibility conditions. Combined with the author’s previous systematic study on the chemical components of Daphne genkwa, the connotation of the material base of Genkwa Flos and Glycyrrhizae Radix et Rhizoma was discussed from the perspective of the weak bond between the active components in this paper, so as to provide reference for further research of the incompatible pair.