Study on mechanism of anti-inflammation and immunoregulation of Shufeng Jiedu Capsule based on network pharmacology / 中草药

ABSTRACT

Objective: To explore the network regulation mechanism of anti-inflammation and immunoregulation of Shufeng Jiedu Capsule (SJC). Methods: Targets of the 28 compounds in SJC were predicted according to the reverse pharmacophore method. Gene ontology (GO) function enrichment and pathway analysis of the targets were analyzed by MAS 3.0 software and Kyoto Gene and Genome Encyclopedia (KEGG) database. Finally, Cytoscape software was used to construct the network pharmacology map. Results: A total of 28 compounds affected 112 pathways through 127 targets, of which 41 targets and 22 pathways were associated with anti-inflammation and immunoregulation. The network of compound-target-pathway-pathology process was also constructed. Conclusion: SJC interferes with multiple biological processes related to anti-inflammation and immunoregulation by acting on several key proteins such as HRAS, MAP2K1, AKT1, MME, and PTPN1. The mechanism of SJC was preliminarily revealed.