Inflammation-immune regulation as a new strategy for prevention and treatment of deep vein thrombosis by Chinese materia medica for invigorating circulation and removing blood stasis / 中草药

ABSTRACT

Deep vein thrombosis (DVT) is a common clinical complication with diversified causes. The high morbidity, mortality and disability rate have made it become one of the important risk factors affecting human health. DVT has long been considered as blood coagulation disorder, but the pathogenesis is still unclear, and increasing evidence now demonstrate that immune system regulation and inflammatory processes are critically involved in DVT initiation and development. Chinese materia medica for invigorating circulation and removing blood stasis has a unique advantage in the prevention and treatment of DVT. Here, we briefly summarize the factors contributing the formation of deep venous thrombosis, especially the role of immune cells and platelet in DVT. Importantly, we also analyze and forecast the prospect of Chinese medicine with immunomodulatory effects in the prevention and treatment of DVT, hoping to shed new light on future development of more effective treatment for DVT and provide guidance of their clinical applications.