Advances in natural products with function of PCSK9 regulation and their action mechanism / 中草药

ABSTRACT

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the highligh of lipid-lowering therapy due to its effect on LDL-C in the cardiovascular field. PCSK9 inhibitor has become the hot spot in biological preparations in these years, but the properties of adverse reaction, high price and injection-methods of biologicals limit its development. Currently, it was reported that many traditional Chinese medicine and natural products had the functions of regulating PCSK9. This paper summarized the regulation and mechanisms of traditional Chinese medicine monomers, active ingredients, compounds and natural products on PCSK9 so as to provide references for the development of small-molecule inhibitors of PCSK9.