Chemical components from Lianhua Qingwen Capsule (III) / 中草药

ABSTRACT

Objective: To study the chemical constituents of Lianhua Qingwen Capsule and illuminate its substance foundation. Methods: The compounds were isolated and purified by LPLC and preparative HPLC from the 30% ethanol fraction of Lianhua Qingwen Capsule macroporous resin column chromatography. Their chemical structures were elucidated by the spectral analyses. Results: 18 compounds were isolated and identified as forsythoside A (1), forsythoside I (2), forsythoside H (3), lugrandoside (4), isolugrandoside (5), ferruginoside A (6), lianqiaoxinoside C (7), calceolarioside C (8), forsythoside E (9), ferruginoside B (10), D-amygdaloside (11), L-amygdaloside (12), sambunigrin (13), cornoside (14), 4-hydroxy-4-methylenecarbomethoxy-cyclohexa- 2,5-dienone (15), liriodendrin (16), liquiritigenin-7-O-β-D-glucopyranoside (17), and 3,4-dihydroxy benzaldehyde (18). Conclusion: Compounds 2-8, 10, and 13-18 are isolated from Lianhua Qingwen Capsule for the first time, and compounds 4-6, 10, 15, and 16 are isolated from single herb in Lianhua Qingwen Capsule compound for the first time. The spectral data in DMSO-d6 solution of compound 8 are reported firstly with 2D NMR spectral data. The above results show the high polar chemical constitutions of Lianhua Qingwen Capsule, which provides more chemical information of Lianhua Qingwen Capsule.