Effect of Zaoren Anshen Priscription combined with escitalopram in treatment of coronary heart disease with anxiety disorder and its mechanism on neurotransmitters / 中草药

ABSTRACT

Objective: To study the effect of self-made Zaoren Anshen Priscription combind with escitalopram in treatment of coronary heart disease with anxiety disorder and its effect on neurotransmitters, and discussion on the mechanism of drug prescription. Methods: A total of 120 cases of CHD with anxiety disorder in Zhumadian Central Hospital from April 2016 to March 2018 were randomly divided into the control group and the experimental group for 60 cases in each group. The two groups were given conventional treatment for coronary heart disease, including Aspirin Enteric-coated Tablets, Metoprolol Succinate Tablets, isosorbide mononitrate, and atorvastatin. The control group was given escitalopram, while the experimental group was treated with Zaoren Anshen Priscription on the basis of the control group. Four weeks as a one course of treatment, three courses in a row. Before and after treatment, the HAMA score, TCM syndrome score, and angina pectoris score were evaluated, and evaluated the effect of coronary heart disease and anxiety, and the serum levels of 5-HT, MPO, NE, NPY were measured. Results:After treatment, the effective rate of coronary heart disease and anxiety in the experimental group was 91.67%, 93.33%, higher than 78.33% and 80% in the control group (P < 0.05); The HAMA score, TCM syndrome score, and angina score in the experimental group were lower than those in the control group (P < 0.05); The 5-HT, NE and NPY in the test group were higher, while MPO was lower than that in the control group (P < 0.05). Conclusion: The treatment of coronary heart disease and anxiety can improve the symptoms of coronary heart disease and anxiety, and improve the curative effect, and was adjusting the level of 5-HT, NE, NPY, and MPO to play the therapeutic effect.