Chemical constituents from leaves of Styrax japonicus / 中草药

ABSTRACT

Objective To study the chemical constituents from the leaves of Styrax japonicus. Methods Seventeen compounds including nine phenylpropanoids and seven other constituents were isolated from the chloroform fraction of the 70% ethanol extract of leaves of S. japonicus, using column chromatography over silica gel and Sephadex LH-20 as well as the method of recrystallization. Results On the basis of physical and chemical properties combined with spectral data analysis, their structures were elucidated as nectandrin B (1), stigmasterol (2), matteucinol (3), eupomatenoid-7 (4), β-stigmasterol (5), dehydrodiisoeugenol (6), 4-oxo- 4[(3β,22E)-stigmasta-5,22-dien-3-yloxy] butanoic acid (7), 4-(3-methory-4-hydroxy) pheny-3-methyl-3-buten-2-one (8), ursolic acid (9), vanillic acid (10), (+)-(7S,8R,8’R)-4,8’-dihydroxy-3-methoxy-1’,2’,3’,4’,5’,6’-hexanorligna-7,7’-lactone (11), (+)-(7S,8R)-4- hydroxy-3-methoxy-1’,2’,3’,4’,5’,6’,7’-heptanorlign 8’-one (12), (2S,3R’)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy- 5-(2-propen-1-yl)-3-benzofuranmethanol (13), vanillin (14), (E)-p-coumaric acid (15), and dihydrokaempferol (16). Conclusion Compounds 1, 3-16 are isolated from this plant for the first time.