A new diterpene glycoside associated from marine-derived Penicillium sp. H1 / 中草药

ABSTRACT

Objective To identify the active metabolites of Penicillium sp. H1 isolated from Beibu Gulf of Guangxi. Methods The isolation and purification of compounds were performed by means of column chromatography with silica gel. And their structures were elucidated through the analysis of UV, MS, NMR, and specific rotations. The bioactivities of compounds against Fusarium oxysporum f. sp. cubense were assayed by paper diffusion. Results Three diterpenes (1—3) were isolated from the fermentation broth of Penicillium sp. H1. Compound 1 was identified as a new compound and named xylarinonericin D. Compounds 2 and 3 were identified as BE-31405 (2) and sordaricin (3), respectively. Compounds 1 and 2 showed moderate antifungal activity against Fusarium oxysporum f. sp. cubense with MIC values of 32.0 μg/mL and 16.0 μg/mL, respectively. Conclusion Compound 1 is a new diterpene glycoside.