Review on neuroprotection effect of Astragali Radix on central nervous system and related toxicology / 中草药

ABSTRACT

Astragali Radix (AR) is one of the most famous drugs for enhancing Qi in Chinese herbal medicines, and shows satisfactory medicinal value. Recently, AR has made significant progress in research of central nervous system (CNS) injury and neurodegeneration. AR and its active ingredients have satisfactory effects on modulation of nerve inflammation, inhibition of apoptosis, enhancement of vascular repair and neuroregeneration. The mechanism may be related to the regulation of microscopic Qi mitochondrial function and the recovery of cell metabolic disorders. In this article, we systematically discuss the pharmacological effects and possible mechanisms of AR from the perspective of the core pathological changes, and evaluate its drug safety through combing of the related toxicology researches to provide a reference for application of AR in CNS disease treatments.