Chemical constituents from Syneilesis aconitifolia / 中草药

ABSTRACT

Objective To study the chemical constituents from Syneilesis aconitifolia. Methods The chemical constituents were separated and purified by silica gel column chromatography and HPLC. Their structures were determined based on spectroscopic analyses. Results Nine sesquiterpenes compounds were isolated and the structures were identified as 3-angeloyloxy-8-methoxy-6,15- epoxy-eremophil-7(11)-en-12,8α-olide (1), β-selinene (2), (-)-ent-6α-methoxyeudesm-4(15)-en-1β-ol (3), 1-oxo-5α,7αH-eudesma-3- en-15-al (4), germacrane alcohol (5), oplopanone (6), 6β,8β-dimethyoxy-10β-hydroxyeremophil-7(11)-en-12,8α-olide (7), 8β,10β- dihydroxy-6β-methyoxyeremophil-7(11)-en-12,8α-olide (8), and 1β,6α-diidroxi-4(15)-eudesmeno (9). Compounds 1, 3, 5, 6, 8, and 9 were tested for their anticancer activity against uterine cancer (HeLa). Conclusion Compound 1 is a new compound, named as syneilesis lactone A. Compounds 2-5, and 7 are isolated from this plant for the first time. Compounds 1, 5, 6, 8, and 9 show inhibitory activity against HeLa.