Drug-containing intestinal absorption solution: A new in vitro pharmacological method of Chinese materia medica / 中草药

ABSTRACT

The chemical composition of Chinese materia medica (CMM) is complex. It is crucial to carry out quality control in pharmacological experiment in vitro of CMM, understand its mechanism, and identify its pharmacodynamic material basis. In recent years, drug-containing intestinal absorption solution (DCIAS), as a new method for evaluating in vitro pharmacological activity, has been used in research of CMM. This article detailed the methodology and development of applying DCIAS to in vitro experiments of CMM with a comparison to other methods. The results showed that DCIAS played an important role in quality evaluation, mechanism analysis and material basis identification of CMM and Chinese herbal compound prescriptions. Meanwhile, DCIAS has the advantages of being simple to operate and cheap to apply. This study provides a basis for the application of DCIAS and a reference for in vitro pharmacological study of CMM.