Study on chemical constituents from sponge-derived fungus Penicillium sp. HPQJ10 / 中草药

ABSTRACT

Objective: To study the secondary metabolites of sponge-derived fungus Penicillium sp. HPQJ10. Methods: The compounds were isolated and purified by chromatographic methods on silica gel, Sephadex-LH20 columns and semi-prep HPLC. The structures were established on the basis of spectroscopic data interpretation. Results: Forteen compounds were isolated and identified as N-[(Z)-2-(4-hydroxyphenyl) ethenyl] formamide (1), 2,4-dimethoxyphenyl acetate (2), 6,8,5′6′-tetrahydroxy-3′- methylflavone (3), 4-hydroxyphenylacetic acid (4), cyclo-(L-Pro-L-Val) (5), cyclo-(L-Pro-L-Leu) (6), diisobutyl phthalate (7), dibutyl phthalate (8), 7-hydroxy-2-(2-hydroxyPropyl)-5-methyl chromone (9), 2-(2,4-dimethoxylphenyl)-3-(4-hydroxybenzyl)-1,2,4-triazole (10), (22E,24R)-ergenol-5,7,22-trien-3β-ol (11), cyclo-(Leu-Pro-Ile-Pro) (12), 2,4-dimethoxybenzoic acid (13), and 3-methoxyphenol (14). Conclusion: Except for compounds 1, 3, 10, and 11, other compounds are isolated from Penicillium sp. for the first time.