Exploration and review on substance basis responsible for "Xuanfa" and its biological mechanisms about "Zhijie" / 中草药

ABSTRACT

Although the basic theory of "Xuanfa Sujiang" has been generally accepted by Chinese medicine practitioners, it is still controversial that traditional Chinese medicine (TCM) theory is combined with modern biology and interpreted by modern science. Based on relevant classical theories, prescriptions, pharmacological substance basis and biological mechanism, we put forward the following points in this paper The effect and function of "Feiqi" governing organ movement depends on the difference about subtype or expression of adrenergic receptors on the post ganglionic fibers dominated autonomic effector. Coincidentally, TCM theory selected different types of natural effective molecules, such as phenylethylamine and its derivatived alkaloid, to achieve a good sympathetic regulation, and just meet the different needs of clinical treatment; The β-AR/cAMP/PKA signaling pathway is the core pathways for positive regulation; The concept of the "Zhijie" is closely related to the balance of myosin light chain phosphorylation and dephosphorylation levels; Prescription compatibility can effectively enhance the crosstalk between adrenergic receptor-related multiple signal pathways, and reflect the advantages of TCM for complex diseases treatment by multi-ingredients and multi-targets.