Study on chemical constituents of Codonopsis pilosula / 中草药

ABSTRACT

Objective: To study the chemical constituents of Codonopsis pilosula. Methods: The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin, silica gel, and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified on the basis of spectroscopic methods including 1H-NMR, 13C-NMR, CD, and MS spectra. Results: Seven compounds were identified as (-)-(8R, 9R, 2E, 6E, 10E)-tetradeca-2, 6, 10-triene-4-yne-8, 14-diol-9-β-D-glucopyranoside (1), phenyl-β-D-glucoside (2), (E)-isoconiferin (3), coniferin (4), syringin (5), apigenin (6), and adenosine (7). Conclusion: Compound 1 is a new compound, named lobetyolin A, and compounds 2 and 3 are all isolated from this plant for the first time.