Analysis on components exposing in rat plasma after oral administration of Baoerkang Powder / 中草药

ABSTRACT

Objective: To analyze the components exposing in rat plasma after oral administration of Baoerkang Powder, and to study the mechanism of Baoerkang Powder and pharmacokinetic behavior. Methods: Components absorbed in rat plasma after oral administration of Baoerkang Powder to rats were analyzed by UPLC tandem High-resolution mass spectrometer. The structures of Baoerkang Powder in rat plasma identified by comparing the retention time, molecular weight, and CID fragmentation patterns with their corresponding compounds reported in the literatures. Results: Twenty-three components in rat plasma were identified after oral administration of Baoerkang Powder to rats for 1 h, including five components confirmed by comparing retention time and information of mass with their reference substances, components confirmed were vitexin, liquiritigenin, hesperetin, glycyrrhetic acid, and ursolic acid. Conclusion: It is suggested that the method could be applied to quick analysis of the components exposing in rat plasma after oral administration of Baoerkang Powder, which is beneficial to studying its mechanism and pharmacokinetic behavior.