Research progress on metabolic regulation of artemisinin / 中草药

ABSTRACT

Artemisinin is widely used for the treatment of malaria. Artemisia annua fielded low artemisinin, which was far behind the requirements. The study on the metabolic regulation of A. annua is an effective way to improve the yield of artemisinin. Metabolic regulation of artemisinin is an effective approach to improve the yield of artemisinin. In this paper, the variety of factors that affect artemisinin content was summarized, including biosynthesis in artemisinin and its branch pathway of key enzyme genes, transcription factors, phytohormones, environmental stress, induction factors, trichomes, etc. By reviewing the research progress of these factors in metabolic regulation of artemisinin, new strategies in conventional secondary metabolic engineering were generalized based on artemisinin and its branch biosynthesis pathway and fresh metabolic engineering based on trichomes. These strategies enriched the pathway in metabolic regulation of artemisinin and put forward a new idea to cultivate transgenic strain of A. annua with good quality and high yield.