Historical story on natural medicinal chemistry: Rapamycin / 中草药

ABSTRACT

The study on natural product chemistry plays an important role in drug development and microbe is one of the main sources of new drugs. Rapamycin is isolated from the bacterium ensconced in a sample of Easter Island's soil, the compound has led to several approved immunosuppressant and anticancer drugs. The researchers studying on the target of rapamycin have got the "Nobel-class" achievements. In this paper, the discovery and study on rapamycin is summarized to provide the references for future related research.