Preparation and in vitro/in vivo evaluation of polydatin solid dispersion / 中草药

ABSTRACT

Objective: Polydatin solid dispersion (PD-SD) was prepared for improving bioavailability. Methods: In this study, PD-SD was prepared by solvent evaporation method with dissolution as index for improving bioavailability. The physicochemical properties of PD-SD were evaluated by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray power diffraction (XRD), and scanning electron microscope (SEM). HPLC was employed to determine the plasma concentration of PD-SD with PD crude drug as reference group in rats after oral administration. Results: FT-IR revealed that there was no new chemical bond between drug and carrier. DSC and XRD results indicated that PD in PD-SD was amorphous. SEM results showed that the morphology of PD-SD was close to irregular globular. The AUCs of PD-SD and PD were 328.79 and 139.70 μg·min/mL after oral administration, respectively. Conclusion: PD-SD is prepared by simple technology. PD-SD significantly improved the in vitro dissolution and oral bioavailability of PD in rats.