Optimization of extraction process of Xiaoer Wenre Oral Liquid based on analgesic and anti-inflammatory pharmacodynamics by central composite design-response surface method / 中草药

ABSTRACT

Objective: To optimize the extraction process of Xiaoer Wenre Oral Liquid (XWOL). Methods: Through the analgesic, anti-inflammatory and antipyretic pharmacological experiments, the best extraction process route was primarily optimized, then taking the volatile oil amount as index, single factor test was adopted to investigate the effects of the soaking time and extracting time on extraction process of volatile oil; With contents of phillyrin, baicalin, and overall desirability as comprehensive evaluation indexes, central composite design-response surface method was adopted to predict the water extraction process. Results: Adding 10 times water, extracting for 6 h, collecting volatile oil and water extract, then the dregs and other medicines were extracted twice with 13 times water, for 80 min each time. Conclusion: The optimized extraction process is reasonable and feasible, and it can be used in a large scale industrial production.