Research process in biosynthesis pathway and regulation mechanism of phenolic acids in roots and rhizomes of Salvia miltiorrhiza / 中草药

ABSTRACT

Phenolic acids with significant biological activity and pharmacological effects are a class of active ingredients in the roots and rhizomes of Salvia miltiorrhiza used for the treatment of cardiovascular and cerebrovascular diseases. With increasing the demand of clinical and market, enhancing the contents and utilization efficiency of phenolic acids in the roots and rhizomes of S. miltiorrhiza has the important practical significance for sustainable development. In this paper, the research progress in study on genomics, proteomics, and metabonomics in recent years was carried out to summarize the biosynthesis pathway, key enzymes genes, regulation mechanism, and bioconversion and utilization of phenolic acids in the roots and rhizomes of S. miltiorrhiza, which lays the scientific foundation for the efficient production and comprehensive utilization of phenolic acids resources in S. miltiorrhiza.