Optimization of ultrafiltration technology for water extract in Cornus officinalis / 中草药

ABSTRACT

Objective: To explore the possibility for the application of ultrafiltration technology using polysulfone (PS) hollow fiber membrane to purlfy the water-extraction of Corni Fructus and optimize the preparation procedure. Methods: The PS membrane of different aperture 5×104, 1×104, and 6×103 were studied on the applicability with water-extraction of Corni Fructus. The proper molecular weight retention was optimized with the removal of liquid impurities and the transformation. Taking the ratios of loganin transmittance and common polymers (pectin, tannin, protein, and starch) retention as indexes, the proper ultrafiltration condition was optimized by response surface method. Results: The PS membrane with interception molecular weight of 1×104 had better separation efficiency and the preferred operation parameters were 0.1 MPa of pressure, 50℃ of liquid temperature, and solution concentration of 0.13 g/mL. Conclusion: The preferred aperture of PS membrane and the operation conditions are feasible for the purification of water-extraction of Corni Fructus, which can improve the production efficiency.