A new phenylpropanoid from Dai Medicine Arundina graminifolia and its anti-tobaco mosaic virus activities / 中草药

ABSTRACT

Objective: For the purpose of finding new bioactive agents from ethnic medicines, the chemical study on Dai Medicine Arundina graminifolia was carried out. Methods: The chemical constituents in the whole plant of A. graminifolia were isolated by silica gel, MCI-GEL resin, Sephadex LH-20 column chromatography, and high performance liquid chromatography (HPLC) method. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The inhibitory activities of compound 1 against tobaco mosaic virus (TMV) replication were tested using the half-leaf method. Results: Four phenylpropanoids, 6-(3-hydroxypropanoyl)-5-hydroxymethyl-isobenzofuran-1(3H)-one (1), coumaric acid (2), ω-hydroxypropioguaiacone (3), and 3-methoxy-4-hydroxy-propyl alcohol (4) were isolated from the whole plant of A. graminifolia. Conclusion: Compound 1 is isolated from the whole plant of A. graminifolia for the first time. Compound 1 is a new compound named Arundina phenylpropanoid. It is tested for its anti-TMV activities. The results show that compound 1 exhibits the potential anti-TMV activities with the inhibitory rate of 22.6%.