A new coumarin from roots of Angelica sinensis and its cytotoxicity / 中草药

ABSTRACT

Objective: To study the chemical constituents from the roots of Angelica sinensis. Methods: The chemical constituents in the roots of A. sinensis were separated and purified through various kinds of chromatographic methods, including silica gel, MCI-Gel, Sephadex LH-20, and RP-HPLC. Their structures were elucidated by spectral data and physical-chemical properties. Results: 6-Hydroxy-3-(4-hydroxyphenyl)-7-methyl-coumarin (1) was isolated from the 95% ethanol extracts of this plant. Conclusion: Compound 1 is a new compound, named Angelica coumarin A. And it displays the cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.8 μmol/L, respectively.