Limonoids from Indian mangrove, seeds of Xylocarpus moluccensis / 中草药

ABSTRACT

Objective: To investigate limonoids in the seeds of an Indian mangrove, Xylocarpus moluccensis. Methods: Compounds were isolated and purified by silica gel, ODS gel column chromatographies, and HPLC. The structures of the obtained limonoids were identified by NMR spectra and ESI-MS. Results: Eighteen limonoids, such as fissinolide (1), 3-propanoylproceranolide (2), 3β- hydroxyangustidienolide (3), 3β-acetoxy-6-deoxy-swietenine (4), febrifugin (5), granatumin I (6), 3-de(2-methylbutanoyl)-3- propanoylcipadesin (7), granatumin H (8), tigloylseneganolide A (9), ruageanin A (10), swietemahonolide (11), khayasin T (12), andhraxylocarpin D (13), granatumin D (14), 7-oxo-7-deacetoxygenunin (15), gedunin (16), methyl angolensate (17), and 20,21,22,23- tetrahydro-23-oxoazadirone (18), were isolated and identified. Conclusion: 3-propanoylproceranolide (2) is a new compound, and compound 3 is a new natural product.