Advances in study on applicability of drug metabolism model in zebrafish / 中草药

ABSTRACT

According to relative research and foreign references, we summarized the experimental method, drug metabolism type, and applicability of drug metabolism model in zebrafish. Zebrafish successfully simulated the mammals in phase I metabolism, phase II metabolism, intestinal bacteria metabolism, and multiway in vivo metabolism. Zebrafish is suitable for in vivo metabolism of trace monomeric compounds and their combinations, and is benefit for the efficient enrichment of metabolites in simple way. It has the advantages of simplity, high efficiency, low cost, and less amount of compound (a few mg) etc. It is a very prospect organisms model for early and rapid prediction of in vivo metabolism of trace elements.