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Antioxidative effects of Kimchi under different fermentation stage on radical-induced oxidative stress
Nutrition Research and Practice ; : 638-643, 2014.
Artículo en Inglés | WPRIM | ID: wpr-85433
ABSTRACT
BACKGROUND/

OBJECTIVES:

Kimchi is a traditional Korean fermented vegetable containing several ingredients. We investigated the protective activity of methanol extract of kimchi under different fermentation stages against oxidative damage. MATERIALS/

METHODS:

Fresh kimchi (Fresh), optimally ripened kimchi (OptR), and over ripened kimchi (OvR) were fermented until the pH reached pH 5.6, pH 4.3, and pH 3.8, respectively. The radical scavenging activity and protective activity from oxidative stress of kimchi during fermentation were investigated under in vitro and cellular systems using LLC-PK1 cells.

RESULTS:

Kimchi exhibited strong radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, superoxide anion, and hydroxyl radical. In addition, the free radical generators led to loss of cell viability and elevated lipid peroxidation, while treatment with kimchi resulted in significantly increased cell viability and decreased lipid peroxidation. Furthermore, the protective effect against oxidative stress was related to regulation of cyclooxygenase-2, inducible nitric oxide synthase, nuclear factor-kappaB p65, and IkappaB expression. In particular, OvR showed the strongest protective effect from cellular oxidative stress among other kimchi.

CONCLUSION:

The current study indicated that kimchi, particularly OptR and OvR, played a protective role against free radical-induced oxidative stress. These findings suggest that kimchi is a promising functional food with an antioxidative effect and fermentation of kimchi led to elevation of antioxidative activity.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Verduras / Peroxidación de Lípido / Supervivencia Celular / Radical Hidroxilo / Superóxidos / Estrés Oxidativo / Células LLC-PK1 / Metanol / Alimentos Funcionales Límite: Animales Idioma: Inglés Revista: Nutrition Research and Practice Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Verduras / Peroxidación de Lípido / Supervivencia Celular / Radical Hidroxilo / Superóxidos / Estrés Oxidativo / Células LLC-PK1 / Metanol / Alimentos Funcionales Límite: Animales Idioma: Inglés Revista: Nutrition Research and Practice Año: 2014 Tipo del documento: Artículo