Nitrogeous chemical constituents from Tinosporae Radix / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1287-1291, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-854389
ABSTRACT
Objective:
To investigate the chemical constituents from Tinosporae Radix (the roots of Tinospora sagittata) and their antiproliferative effects in cancer cells.Methods:
The compounds were isolated and purified by means of silica gel, ODS, and Sephadex LH-20 column chromatography. The structures were identified on the basis of physicochemical properties and spectroscopic analysis. The antiproliferative effects in HL-60 and MCF-7 cells were tested by Trypan blue and MTT methods, respectively.Results:
Nine compounds were isolated and their structures were identified as tetrahydropalmatine (1), tetrahydrojatrorrhizine (2), jatrorrhizine (3), palmatine (4), neoechinulin A (5), echinuline (6), N-trans-feruloyltyramine (7), uracil (8), and triethylamine hydroiodide (9).Conclusion:
Among them, compounds 5, 6, 8 and 9 are isolated from the plants of Tinospora Miers for the first time. Compounds 1, 3-5 and 7 show the moderate antiproliferative effects in HL-60 cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2015
Tipo del documento:
Artículo
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