Your browser doesn't support javascript.
loading
Absorption characteristics of liposome encapsulated Centella asiatica total glucosides / 中草药
Chinese Traditional and Herbal Drugs ; (24): 1487-1492, 2015.
Artículo en Chino | WPRIM | ID: wpr-854406
ABSTRACT

Objective:

To study the intestinal absorption characteristics of the liposome encapsulated Centella asiatica total glucosides in vitro.

Methods:

Dialysis method was adopted to study the stability of the liposome encapsulated C. asiatica total glucosides in both PBS and Tyrode solution. RP-HPLC was adopted to detect the chromatographic profile of the sample solutions. To research the in vitro intestinal absorption properties of C. asiatica total glucosides and its liposome in isolated everted intestine model, the cumulative absorptive percentages of them in the different intestines are calculated and the cumulative absorption curve of them are drawn, in which the cumulative absorptive percentages of them are calculated by the amount of asiaticoside, and the intestinal absorption effects of them are compared.

Results:

The results show that the lipsome encapsulated C. asiatica total glucosides could exist stably in the PBS and Tyrode solution. C. asiatica total glucosides and its liposome could be absorbed in the small intestine and have no significant absorption site. The uptake of asiaticoside in ileum increased with time prolonging, and there was no absorptive saturation within 120 min. During the ileum absorption, the liposome encapsulated C. asiatica total glucosides have a higher percentage and a higher quantity of cumulative absorption than the drug of C. asiatica total glucosides, which showed that apparent permeation coefficient was higher significantly.

Conclusion:

The encapsulated C. asiatica total glucosides could promote the absorbtion of C. asiatica total glucosides in the ileum of rats, which provides the experimental evidence for the development of the oral dosage forms of C. asiatica total glucosides.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2015 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2015 Tipo del documento: Artículo