Meta-analysis on Ningmitai Capsule combined with antibiotics therapy for chronic prostatitis / 中草药

ABSTRACT

To evaluate if Ningmitai Capsule combined with antibiotics therapy is safer and more effective than simple antibiotics therapy for chronic prostatitis, we firstly retrieved the China journal full-text database (CNKI), China's outstanding master's/doctoral dissertation database, Wan Fang database, VIP science and technology periodical database, MEDLINE, and EMBASE. Secondly, we selected research literatures from 2000 to 2013 on Ningmitai Capsule combined with antibiotics therapy for chronic prostatitis. Then, the data were filtered by Cochrane system evaluation method and conducted for Meta-analysis on the effectiveness, chronic prostatitis symptoms index (NIH-CPSI) and microscopy count of white blood cell in expressed prostatic secretion (EPS-WBC) via Stata 12.0 software. Finally, 11 articles including 2 079 samples were totally involved. The Meta-analysis results showed that compared with simple antibiotics treatment, Ningmitai Capsule combined with antibiotics therapy significantly increased the cure rate[OR=2.47, 95% CI (2.08, 2.93)] and lowered NIH-CPSI[WMD=-8.14, 95% CI (-9.39, -6.90)] as well as EPS-WBC[WMD=-6.14, 95% CI (-8.11, -4.17)]. So the study suggests that Ningmitai Capsule can significantly improve the cure rate and related indicators of simple antibiotics therapy for chronic prostatitis, which provides certain references for improving clinical treatment.