Chemical constituents of Evodia lepta in Pattra medicine / 中草药

ABSTRACT

Objective: To study the chemical constituents of Pattra medicine Evodia lepta from Xishuangbanna of Yunnan province, China. Methods: The chemical constituents were isolated and purified by chromatographic techniques, and identified by NMR, MS, and other spectral methods with chemical hydrolysis. Results: In 95% ethanol extract from the leaves of E. lepta, four compounds were isolated and their structures were identified as 2, 4, 6-trihydroxyacetophenone-3, 5-di-C-β-D-glucoside (1), 2, 4, 6-trihydroxy- acetophenone-3, 5-di-C-β (6'-O-E-p-coumaroyl)-D-glucoside (2), 2, 4, 6-trihydroxyacetophenone-3, 5-di-C-β(6'-O-Z-p-coumaroyl)- D-glucoside (3), and 2, 4, 6-trihydroxyacetophenone-3, 5-di-C-β (6'-O-E-cinnamoyl)-D-glucoside (4), respectively. Conclusion: Compounds 2-4 are new compounds named leptabiside A, B, and C, respectively. Compound 1 is obtained from domestic E. lepta for the first time.