Study on alkaloids from Corydalis saxicola and their anti-oxidative activities / 中草药

ABSTRACT

Objective: To study the alkaloids from Corydalis saxicola and their anti-oxidative activities. Methods: The alkaloids were separated and purified by various column chromatography and identified according to their spectral analyses. The anti-oxidation activities were investigated on DPPH radical scavenging assay. Results: Sixteen compounds were obtained and identified as cavidine (1), stylopine (2), canadine (3), tetrahydropalmatine (4), cheilanthifoline (5), scoulerine (6), protopine (7), dehydrocheilanthifoline (8), dehydroisoapocavidine (9), berberine (10), dehydrodiscretamine (11), chelerythrine (12), dehydrocavidine (13), corypalline (14), isocorydine (15), and pallidine (16). The alkaloids from C. saxicla were measured by the model of scavenging the stable DPPH radical, which showed a concentration dependent scavenging effect. Conclusion: Compounds 3, 5, 8, 11, and 16 are isolated from C. saxicola for the first time. Compounds 5 and 16 show the strong anti-oxidative activities.