Chemical constituents from Ampelopsis cantoniensis and their anti-angiogenic activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 900-905, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-854619
ABSTRACT
Objective:
To study the chemical constituents from Ampelopsis cantoniensis and their anti-angiogenic activities.Methods:
The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis. The anti-angiogenic activities of the compounds isolated were evaluated using a zebrafish model.Results:
Fifteen compounds were obtained from the ethyl acetate fraction in the 90% ethanol extract of A. cantoniensis and their structures were identified as cantonienol (1), nootkatone (2), aromadendrane-4β, 10β-diol (3), abscisic acid (4), 12-oxo-hardwickiic acid (5), betulinic acid (6), platanic acid (7), vanillic acid (8), resveratrol (9), nectandrin B (10), nectandrin A (11), 3, 5, 7-trihydroxychromone (12), 5, 7, 3', 4', 5'-pentahydroxyflavanone (13), taxifolin (14), and myricitrin (15).Conclusion:
Compound 1 is a new sesquiterpene named cantonienol. Compounds 2-7 and 10-12 are isolated from the plants of Ampelopsis Michaux for the first time, and the other compounds are firstly reported in this plant. Compounds 9, 11, and 12 exhibit the weak anti-angiogenic activity when evaluated using a zebrafish model.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2014
Tipo del documento:
Artículo
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