Effect of Huoxiang Zhengqi Soft Capsule on gastric motility and gastrointestinal hormones in functional dyspepsia patients with spleen deficiency and predominant dampness / 中草药

ABSTRACT

Objective: To explore the possible pathogenesis for functional dyspepsia (FD) patients with spleen deficiency and predominant dampness and investigate the intervention by Huoxiang Zhengqi Soft Capsule (HZSC). Methods: One hundred FD patients with spleen deficiency and predominant dampness were divided in two groups the control and treatment groups. The patients in the treatment group were given HZSC+starch tablets and those in the control group were given Domperidone+simulated agent for treatment. After 28 d, the indexes of the symptom scores before and after the treatment, the efficacy judgement standard, gastric emptying, motilin (MTL), gastrin (GAS), nitric oxide (NO), and 5-hydroxytryptamine (5-HT) were observed and compared with the positive and healthy controls. Results: After the treatment by HZSC, the scores of epigastric fullness, early satiety, mouth sticky, nausea, vomiting, and defecate for patients were obviously decreased (P0.05). In the Domperidone treatment group there was no difference in the scores of epigastric fullness, early satiety, mouth sticky, nausea, vomiting, and defecate for patients (P>0.05). HZSC showed the significantly promoting effects on the gastric emptying of FD patients (P0.05). HZSC could increase MTL content obviously (P<0.05). Conclusion: HZSC could ameliorate the clinical symptoms in FD patients with spleen deficiency and predominant dampness, improve the gastric emptying, and regulate the gastrointestinal hormone levels.