Chemical constituents from fallen leaves of Populus alba × P. berolinensis / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3276-3281, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-855008
ABSTRACT
Objective:
To study the chemical constituents from the fallen leaves of Populus alba × P. berolinensis and the inhibitory activity of salicin derivatives against SGC-7901 cell.Methods:
The chemical constituents were isolated and purified on the basis of silica gel column chromatography and HPLC. The structural elucidation was performed according to the physicochemical properties and spectroscopic analysis. The inhibitory activity of salicin derivatives on human gastric carcinoma cells SGC-7901 in vitro proliferation was determined by MTT method.Results:
Sixteen compounds were isolated and identified as tremuloidin (1), populin (2), chaenomeloidin (3), 4'-O-benzoylsalicin (4), salicin (5), tremulacin (6), poliothrysin benzoate (7), catechol (8), benzoic acid (9), tremulacinol (10), 6'-O-benzoylsalicin-7-salicylate (11), salicylol (12), salicortin (13), 7-O-acetyl-3'-O-benzoylsalicin (14), 7-O-acetyl-4'-O-benzoylsalicin (15), and 6'-O-acetyl-2'-O-benzoylsalicin (16), respectively. The inhibitory activity of compounds 7 and 11-13 on the in vitro proliferation of SGC-7901 cell was indicated by MTT and IC50 values were 71.0, 122.5, 212.7, and 257.8 μmol/L.Conclusion:
Compounds 4, 7, 10, 11, 14-16 are isolated from this plant for the first time. Compound 7 shows the inhibitory activity against SGC-7901 in vitro proliferation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2013
Tipo del documento:
Artículo
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