Lipase-catalyzed synthesis of cholesteryl vinyl hemi-sebacate for selective targeting of liposomes in organic media / 中草药
Chinese Traditional and Herbal Drugs
; (24): 3289-3295, 2013.
Article
en Zh
| WPRIM
| ID: wpr-855010
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WPRO
ABSTRACT
Objective: To synthesize cholesteryl vinyl hemi-sebacate from cholesterol and divinyl sebacate in non aqueous phase. Methods: TLC, MS, and NMR were used to identify the structure of production; the technological conditions of enzymatic esterification were determined through orthogonal test. Results: The best condition: isooctane 5 mL, reaction temperature 35°C, reaction time 24 h, Candida rugosa Lipase 10 mg/mL, molar ratio of cholesterol to divinyl sebacate 1:6. Conclusion: The highest esterification rate is above 95%.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional and Herbal Drugs
Año:
2013
Tipo del documento:
Article