Studies on sustained release solid dispersion of tanshione composition / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2391-2396, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-855155
ABSTRACT
Objective:
To prepare the sustained release solid dispersions of tanshinone composition with the intention of improving drug dissolution and controlling drug release.Methods:
The glycerin monostearate (GMS) and polyethylene oxide (PEO) were used as composite carriers to prepare tanshinone solid dispersions by solvent melting method and the in vitro dissolution of tanshinone solid dispersions was performed. The structure of solid dispersions was characterized by SEM, DSC, XRD, and FTIR.Results:
When the ratio of drug to composite carriers (GMS-PEO 21) was 18, the solid dispersions had a better sustained release effect, the accumulative drug-release percent in vitro at 12 h was over 90%, and the results from the phase analysis indicated that the tanshinone composition existed in carriers as amorphous state.Conclusion:
The in vitro dissolution of tanshinone is greatly improved by the solid dispersions with GMS-PEO as its carriers. And it exhibits excellent release characteristics in vitro with the actual applied value.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2013
Tipo del documento:
Artículo
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