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Preparation of puerarin self-microemulsifying osmotic pump controlled-release capsule / 中草药
Chinese Traditional and Herbal Drugs ; (24): 1568-1573, 2013.
Artículo en Chino | WPRIM | ID: wpr-855276
ABSTRACT

Objective:

Through the preparation of puerarin self-microemulsifying osmotic pump controlled-release capsule and controlled-release insoluble drug to improve the bioavailability of puerarin.

Methods:

Through the construction of self-microemulsifying osmotic pump controlled-release capsule of puerarin to do quantitative determination using microemulsion chromatography method. Through the single factor investigation, the three influencing factors were determined dosage of penetration enhancer NaCl, coating weight, and porogen PEG 400. The optimal prescription was predicted by using central composite design and response surface optimization.

Results:

The formulation for puerarin self-microemulsifying osmotic pump controlled-release capsule was puerarin 0.07 g, ethyloleate 0.25 g, Polysorbate 80 0.45 g, PEG 400 0.3 g, mannitol 1.07 g, and NaCl 1.07 g. Based on the release of preparation and prediction of prescriptions in 4, 8, and 12 h, the controlled-release capsule conformed to the zero-order release model.

Conclusion:

Self-microemulsifying osmotic pump capsule could solve the controlled-release of insoluble drugs.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2013 Tipo del documento: Artículo