In vivo absorptive dynamics of arctiin in intestine of rats / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 727-730, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-855451
ABSTRACT
Objective:
To investigate the in vivo absorptive characteristic of arctiin in small intestine of rats.Methods:
The intestine absorption model of arctiin was established by in vivo intestinal perfusion method. The absorption rate constants (Ka), absorption half time (t1/2), absorption percent of per unit of time (P), and apparent permeability coefficient (Papp) were calculated and compared to investigate the absorptive dynamics of arctiin in intestine of rats.Results:
At the concentration range of 10-50 μg/mL, Ka, t1/2, P, and Papp showed no significant difference, and had no connection with concentration of arctiin.Conclusion:
Arctiin complies with the first-order absorptive kinetics and the absorptive mechanism in intestine may be passive transport.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2013
Tipo del documento:
Artículo
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