Effects of Xiongshao Decoction on immune liver fibrosis in rats / 中草药

ABSTRACT

Objective To research the effects of Xiongshao Decoction (XSD) on immune liver fibrosis in rats. Methods Eighty-four SD rats were randomly divided into normal control group, model group, Fuzheng Huayu (FZHY) Capsule group, XSD prevention group, XSD high-dose and low-dose groups (15.8 and 7.9 g/kg). The hepatic fibrosis model was induced by injecting porcine serum to the abdominal cavity of rats. To observe the effects of XSD on the serum hepatic function of rats ALT, AST, ALB, and AJG, the serum marker of hepatic fibrosis hyaluronic acid (HA), laminin (LN), procollagen III (PCIII), and collogen IV (CIV), and hepatic tissue pathomorphology as well. Results Compared with the model group, the levels of ALT, AST, HA, LN, and PCIII in every XSD treatment group were obviously decreased (P<0.05, 0.01), the levels of ALB and A/G were obviously increased (PO.01). The CIV level of serum in XSD prevention group was significantly decreased (P<0.05) and the degrees of hepatocyte degeneration and necrosis in all treatment groups were lower, with less liver fibrosis, especially those in XSD prevention group and high-dose group. Conclusion XSD could not only relieve the degree of liver cells damage of immune hepatic fibrosis in rats, improve hepatic function of them, and regulate the extracellular matrix metabolism, but also arrest the hepatic fibrosis or make it reversed.